MAO-IN-M30 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively).

Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.(In Vitro):MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.(In Vivo):MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.

M 30 dihydrochloride

Others

Other Targets

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64821-19-8

299.2

C14H14N2O.2HCl

>98% (HPLC)

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CN(CC#C)CC1=C2C(N=CC=C2)=C(O)C=C1.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years