
MAO-IN-M30 dihydrochloride
CAS No. 64821-19-8
MAO-IN-M30 dihydrochloride ( M 30 dihydrochloride )
产品货号. M28155 CAS No. 64821-19-8
有效的脑选择性单胺氧化酶 (MAO) 抑制剂(MAO-A 和 MAO-B 的 EC50 值分别为 37 和 57 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1272 | 有现货 |
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10MG | ¥1831 | 有现货 |
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25MG | ¥3046 | 有现货 |
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50MG | ¥4544 | 有现货 |
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100MG | ¥6391 | 有现货 |
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500MG | ¥13446 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称MAO-IN-M30 dihydrochloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述有效的脑选择性单胺氧化酶 (MAO) 抑制剂(MAO-A 和 MAO-B 的 EC50 值分别为 37 和 57 nM)。
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产品描述Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.(In Vitro):MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.(In Vivo):MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.
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体外实验MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:0.25?nM Incubation Time:72 hours Result:Significantly increased cell viability to ~90% after exposure to Dexamethasone.Cell Viability Assay Cell Line:PC12 cells Concentration:0-10 μMIncubation Time:24 hours Result:Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.
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体内实验MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities. Animal Model:Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)Dosage:0.5, 2.5 mg/kg Administration:P.o.; once daily for 14 consecutive days Result:Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.
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同义词M 30 dihydrochloride
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number64821-19-8
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分子量299.2
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分子式C14H14N2O.2HCl
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 2 mg/mL (6.68 mM)
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SMILESCN(CC#C)CC1=C2C(N=CC=C2)=C(O)C=C1.Cl.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Schettgen T, Weiss T, Angerer J. Biological monitoring of phenmedipham: determination of m-toluidine in urine. Arch Toxicol. 2001 May;75(3):145-9.