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MAO-IN-M30 dihydrochloride

CAS No. 64821-19-8

MAO-IN-M30 dihydrochloride ( M 30 dihydrochloride )

产品货号. M28155 CAS No. 64821-19-8

有效的脑选择性单胺氧化酶 (MAO) 抑制剂(MAO-A 和 MAO-B 的 EC50 值分别为 37 和 57 nM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1272 有现货
10MG ¥1831 有现货
25MG ¥3046 有现货
50MG ¥4544 有现货
100MG ¥6391 有现货
500MG ¥13446 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MAO-IN-M30 dihydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    有效的脑选择性单胺氧化酶 (MAO) 抑制剂(MAO-A 和 MAO-B 的 EC50 值分别为 37 和 57 nM)。
  • 产品描述
    Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.(In Vitro):MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.(In Vivo):MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities.
  • 体外实验
    MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:0.25?nM Incubation Time:72 hours Result:Significantly increased cell viability to ~90% after exposure to Dexamethasone.Cell Viability Assay Cell Line:PC12 cells Concentration:0-10 μMIncubation Time:24 hours Result:Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.
  • 体内实验
    MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities. Animal Model:Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)Dosage:0.5, 2.5 mg/kg Administration:P.o.; once daily for 14 consecutive days Result:Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.
  • 同义词
    M 30 dihydrochloride
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    64821-19-8
  • 分子量
    299.2
  • 分子式
    C14H14N2O.2HCl
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 2 mg/mL (6.68 mM)
  • SMILES
    CN(CC#C)CC1=C2C(N=CC=C2)=C(O)C=C1.Cl.Cl
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Schettgen T, Weiss T, Angerer J. Biological monitoring of phenmedipham: determination of m-toluidine in urine. Arch Toxicol. 2001 May;75(3):145-9.
产品手册
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